Reticular.ai: Accelerating Drug Discovery with Interpretable AI

Reticular.ai is a cutting-edge AI platform dedicated to de-risking drug discovery and advancing protein engineering through reliable, interpretable, and steerable AI systems. Designed for researchers and innovators in biopharma, it leverages AI-curated knockout cohorts and rich human datasets to enable confident target validation and significantly accelerate drug development pipelines. The platform's research-driven foundation includes breakthrough work on sparse autoencoders (SAEs) for protein language models, enhancing biological insight discovery and contact map prediction. With a commitment to transparency and innovation, Reticular.ai publishes its findings and plans to release code, trained models, and visualization tools to support scientific advancement. Backed by leading investors from frontier AI labs and top biopharmaceutical companies, and operating from offices in San Francisco and Boston, Reticular.ai stands at the intersection of AI and life sciences, offering a powerful tool for researchers seeking deeper understanding and faster results in complex biological systems.

Key Features:

• AI-curated knockout cohorts for robust target validation
• Access to rich, high-quality human datasets
• Interpretable and steerable AI systems for protein engineering
• Research on sparse autoencoders (SAEs) scaled to ESM2-3B for mechanistic insights
• Matryoshka SAEs for hierarchically organized feature learning in protein models
• Enhanced biological concept discovery and contact map prediction
• Case studies demonstrating neuron-level interpretability (e.g., catalytic serines in serine proteases)
• Future release of open-source code, trained models, and visualization tools
• Support for patent and intellectual property due diligence via AI-powered search
• Secure, compliant data handling with privacy protections and user rights

Pricing: Reticular.ai offers a free access tier for research and exploration, with premium subscription plans available for advanced features and enterprise use. Pricing details are available upon request through the platform’s demo or contact channels.

Conclusion: Reticular.ai is a transformative force in biopharmaceutical research, combining deep scientific insight with state-of-the-art interpretable AI to unlock faster, more reliable drug discovery and protein engineering outcomes.